Endocrine Abstracts

Purpose: To assess the level of biomarkers of early kidney damage (urinary and plasma cystatin C) in patients with prediabetes and to characterize their association with risk factors for the development of nephropathy.Materials and methods: The object of the study were 60 patients (32% men, 68% women) with early disorders of carbohydrate metabolism (impaired fasting glycemia (IFG) and impaired carbohydrate tolerance (IGT), WHO criteria, 2009). The mean a...

Purpose: To study the frequency of polymorphic alleles and genotypes of the PPARG (rs 1801282) gene and its effect on carbohydrate and lipid metabolism in patients with prediabetes.Materials and methods: The object of the study were 60 patients (32% men, 68% women) with early disorders of carbohydrate metabolism (WHO criteria, 2009). The mean age was 44.3 ± 7.8 years. The average value of fasting glycemia - 5.7±0.42 mmol/l, the average level of gly...

Introduction: Obesity and type 2 diabetes mellitus (T2DM) are commonly associated with coronary artery disease (CAD). Recent studies demonstrated that microRNAs (miRNAs) are involved in the pathogenesis of CAD.Aim: To study miRNA-26a, microRNA-33a and microRNA-33b expression in patients with obesity.Methods: MiRNAs were detected in peripheral blood samples of 66 patients, aged 48–65 years. Patients with BMI 30.0–39.9 kg/m...

Introduction: Obesity and diabetes mellitus type 2 (T2DM) are considered as one of the major risk factor for coronary heart disease (CHD) development, but the mechanisms beyond this relationship still need to be clarified. miRNAs are supposed to be involved in regulatory mechanisms in this relationship.Aim: To determine miRNAs expression in patients with obesity and T2DM.Methods: MiRNAs were detected in peripheral blood of 43 patie...